Testing Endothelial Function and its Clinical Relevance
نویسندگان
چکیده
منابع مشابه
Endothelial function and dysfunction: testing and clinical relevance.
Atherosclerosis begins in childhood, progresses silently through a long preclinical stage, and eventually manifests clinically, usually from middle age. Over the last 30 years, it has become clear that the initiation and progression of disease, and its later activation to increase the risk of morbid events, depends on profound dynamic changes in vascular biology.1 The endothelium has emerged as...
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Clinical utility of endothelial function testing: ready for prime time?
The arterial endothelium comprises cells resting on a basement membrane that exert autocrine, paracrine, and endocrine functions. This monolayer of endothelial cells plays a crucial role in the regulation of vascular tone in part by the release of vasoactive substances, notably NO, endothelin, prostacyclin, and angiotensinogen.2–4 In addition, endothelial cells are involved in the modulation of...
متن کاملEndothelial function and clinical outcome.
U nder pro-atherosclerotic conditions, endothelial cells lose the ability to produce bioactive nitric oxide and demonstrate increased expression of vasoconstrictor, pro-inflammatory, and pro-thrombotic factors. The available evidence suggests that these alterations in endothelial phenotype contribute to the formation, progression, and rupture of atherosclerotic lesions. There currently is great...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2013
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.14340